Orbitrap Fusion Tribrid Mass Spectrometer (ETD)

Manufacturer: Thermo Fisher Scientific

The Orbitrap Fusion Tribrid Mass Spectrometer is a high-resolution, high-sensitivity proteomics platform that integrates three mass analyzers—Quadrupole, Ion Trap, and Orbitrap—into a single system. Equipped with Electron Transfer Dissociation (ETD), this instrument provides exceptional flexibility for comprehensive protein identification, quantification, and structural characterization.

The system supports multiple fragmentation modes, including HCD, CID, and ETD, enabling optimized analysis across a wide range of proteomic applications. ETD is particularly powerful for the confident localization of labile and highly charged post-translational modifications, making the Orbitrap Fusion an ideal choice for advanced PTM-focused studies.

With fast scan speeds, high mass accuracy, and robust performance, the Orbitrap Fusion serves as a cornerstone instrument for deep proteome coverage, quantitative workflows, and method development within a proteomics core facility.

Key Capabilities & Applications
  • Global and deep shotgun proteomics
  • Post-translational modification (PTM) analysis
    • Phosphorylation
    • Ubiquitination
    • SUMOylation
    • Other labile or high-charge PTMs (ETD-enabled)
  • Quantitative proteomics
    • TMT / TMTpro multiplexed workflows
    • Label-free quantification (LFQ)
  • Protein–protein interaction and complex analysis
  • Chemical biology and method-development studies
  • High-throughput and complex experimental designs

Core Value

This platform enables the proteomics core to deliver high-quality, reproducible, and scalable mass spectrometry data for both routine and cutting-edge proteomics projects. It supports diverse user needs ranging from standard protein identification to sophisticated PTM mapping and customized experimental workflows.

Vanquish™ UHPLC – TSQ Quantis™ Plus LC–MS/MS System

Manufacturer: Thermo Fisher Scientific

The Vanquish™ UHPLC – TSQ Quantis™ Plus system is a high-sensitivity, high-robustness triple quadrupole LC–MS/MS platform optimized for targeted quantitative analysis. Combining ultra-high-pressure liquid chromatography with a fast, precise triple quadrupole mass analyzer, this system delivers exceptional sensitivity, selectivity, and reproducibility.

The Vanquish UHPLC provides highly stable, low-dead-volume separations, while the TSQ Quantis Plus enables high-performance multiple reaction monitoring (MRM) for confident quantification across complex biological matrices. This configuration is ideally suited for routine, high-throughput quantitative workflows in a shared core environment.

Within a core facility, this system serves as a gold-standard platform for targeted proteomics, metabolomics, and small-molecule quantification.

 
Key Capabilities & Applications
  • Targeted LC–MS/MS using MRM / SRM
  • Absolute and relative quantification
  • Targeted proteomics
    • Peptides and protein biomarkers
    • Verification and validation studies
  • Metabolomics and lipidomics
  • Small-molecule and drug analysis
  • High-throughput, highly reproducible workflows

 

Core Value

The Vanquish–TSQ Quantis Plus platform enables the core facility to provide robust, quantitative mass spectrometry services with outstanding sensitivity and long-term stability. It complements high-resolution Orbitrap-based discovery systems by offering cost-effective, scalable, and highly reproducible targeted measurements, making it ideal for validation studies, large cohorts, and routine assays.

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